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March Madness Betting Guide: Sweet 16, Friday

Can Houston pull off the upset against a potentially shorthanded Kentucky squad?

The second set of Sweet 16 games take place Friday and it is about as close to chalk as you can get. The East and Midwest regions are made up of the 1, 2, 3, and 4 seeds and 1, 2, 3, and 5 seeds, respectively with some prestigious, heavy-hitter programs playing Friday.

With the likes of Duke, Kentucky, North Carolina, and Michigan State in action, there is certainly good reason to cancel those Friday plans, especially when you consider our projections like each game to be relatively close. Big-name teams playing competitive games for the right to meet each other in the Elite 8 -- and did we mention Zion is playing? What more do you need? Let's get down to brass tacks!

Using our models as a guide, here are our best bets for Friday.

Please note that lines are subject to change throughout the day after this article is published. Please check here to make sure you're seeing the most updated information.

(4) Virginia Tech Hokies vs. (1) Duke Blue Devils

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